Annual review of the environment.
نویسندگان
چکیده
-Experiments were undertaken with DMBA -induced mammary tumours of the rat to determine the anti-tumour properties of a new and potent luteinizing hormone-releasing hormone (LH-RH) agonist, [D-Ser(But) 6AzglylO]-LH-RH (ICI 118630). Tumours were classified according to their oestrogen-receptor (ER) content. Twice daily i.m. injections of either 5 ,ug or 0-5 ,ug ICI 118630 in saline were as effective as ovariectomy or tamoxifen therapy in causing the regression of ER+ DMBA-induced mammary tumours. ERmammary tumours showed a more equivocal overall response to ICI 118630, some tumours progressing, others regressing. About one-third of the ER+ tumours disappeared in the 20-day treatment period. Those tumours which did regrow after the cessation of treatment proved to be hormone-dependent. In addition to the inhibitory effects of the LH-RH agonist on pre-existing tumours, ICI 118630 also reduced the total number of new tumours formed during and after treatment.
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 107 شماره
صفحات -
تاریخ انتشار 1999